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 Newsgroups: alt.drugs,alt.drugs.chemistry
From: osiris@netcom.com (Jon M. Taylor)
Subject: Methaminorex synthesis
Message-ID: <osirisCv5AtD.Asr@netcom.com>
Date: Fri, 26 Aug 1994 13:58:24 GMT


Synthesis of Methylaminorex: US Patent #3,161,650

	A mixture of 300cc of methanol and 50cc of water is used to dissolve 
about 35g (.187 mole) of 2-amino-1-phenyl-1-propanol hydrochloride and 16.9g 
(0.411 mole) of sodium acetate.  To this solution there is added a 
solution of 21.6g (0.206 mole) of cyanogen bromide in 200cc of methanol.  
The mixture is stirred for one half hour at room temperature and then 
concentrated under vacuum to remove the methanol.  The residue is taken 
up in water and the resulting aqueous solution is made strongly basic with 
10% sodium hydroxide and then saturated with potassium carbonate.  The 
resulting precipitate of the crude product is filtered off, washed twice 
with water and dried.  The yield of 2-amino-4-methyl-5-phenyloxazoline if 
12g (m. 155.5-158.5 degrees).  After recrystallization from benzene, the 
product melts at 154.5-156 degrees.

-- 
Jon M. Taylor          | Atheism - Computers - The Internet - Fractals 
osiris@netcom.com      | Recreational Drugs - Punk Music - Martial Arts
"Killing time, waiting | Libertarianism - Science Fiction - Science Fact
for the singularity"   | /\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\